- The Juan Bautista de Anza National Historic Trail (Anza Trail) is a 1,210-mile route that runs in the US from Nogales, Arizona to San Francisco, California ... - The trail connects history, culture, and outdoor recreation - The trail follows the route of Spanish commander Juan Bautista de Anza II and his expedition from 1775-1776 ... some 300 people traveled over 1,200 miles to settle Alta California - Key route points in southern Arizona are the Tubac Presidio and San Xavier del Bac mission www.nps.gov/juba/index.htm